Recent transmission analysis of Mycobacterium tuberculosis isolated from rapidly growing population region in Hangzhou China using 15-Locus MIRU-VNTR.

BACKGROUND

Hangzhou, Zhejiang's capital, experienced rapid population growth from 2013 to 2023, with significant increases in 2019 and 2020.Yuhang District stood out with the most rapid population growth. The proportion of immigrant tuberculosis patients in Yuhang District remained at a high level and the prevalence of tuberculosis was severe.

OBJECTIVE

To explore the impact of the rapid growth of new permanent residents in the region on tuberculosis transmission and whether there is transmission between local residents and immigrants.

METHODS

We selected 91 Mycobacterium tuberculosis for MIRU-VNTR genotyping isolated from Yuhang District in 2019-2020.

RESULTS AND

CONCLUSION

The Beijing genotype was the prevalent strains in circulation within this region. Nine transmission clusters were identified, with five involving both local and immigrant populations, indicating transmission between immigrant and native. The results also raised our concerns about TB control and prevention in the Nanyuan Subdistrict of Yuhang District. The minimum estimate of the proportion of TB cases related to recent transmission was 9.89 % lower than that of previous study on 66 MDR - TB. This result reiterated the heightened tendency of MDR-TB strains to cluster and suggested a greater propensity for MDR - TB transmission than that of Non - MDR pulmonary tuberculosis.