Journal of pain research · 2019
Ultrasound-guided continuous serratus anterior plane block: dexmedetomidine as an adjunctive analgesic with levobupivacaine for post-thoracotomy pain. A prospective randomized controlled study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Abdallah Nasr M, Bakeer Ahmed H, Youssef Rasha B, Zaki Hany V, Abbas Dina N
Аннотация
INTRODUCTION: Systemic lupus erythematosus (SLE) is a complex autoimmune disease influenced by genetic, environmental, and immunological factors. Variations in cytokine genes, including tumor necrosis factor α (TNF-α) and interleukin-10 (IL-10), have been implicated in SLE pathogenesis, but their associations remain uncertain owing to conflicting study results.
MATERIAL AND METHODS: A systematic search of the Google Scholar, PubMed, and Embase databases was conducted to examine TNF-α (rs1800629) and IL-10 (rs1800896) polymorphisms in SLE. Eligible studies were selected based on specific inclusion criteria, and data were independently extracted. Quality assessment was performed using the Newcastle-Ottawa Scale, and the Hardy-Weinberg equilibrium was evaluated. Meta-analyses were conducted using Cochrane Rob Tool 2 and Review Manager version 5.4 to determine odds ratios and 95% confidence intervals.
RESULTS: According to the meta-analysis, a significant association was found between SLE risk and TNF-α-308 G/A polymorphism in allelic, dominant, and heterozygote models. However, no association was found between homozygous and recessive models. Interleukin-10 polymorphisms were not significantly associated with SLE risk in any model. Ethnicity-specific analysis revealed a significant association between the TNF-α allele and SLE susceptibility in Asian populations but not in Caucasians.
CONCLUSIONS: This meta-analysis identified a strong correlation between the TNF-α-308 G/A polymorphism and SLE susceptibility, particularly in Asian populations. However, no association was found between IL-10 polymorphisms and SLE. More extensive studies with diverse populations are required to validate and enhance these findings.
MATERIAL AND METHODS: A systematic search of the Google Scholar, PubMed, and Embase databases was conducted to examine TNF-α (rs1800629) and IL-10 (rs1800896) polymorphisms in SLE. Eligible studies were selected based on specific inclusion criteria, and data were independently extracted. Quality assessment was performed using the Newcastle-Ottawa Scale, and the Hardy-Weinberg equilibrium was evaluated. Meta-analyses were conducted using Cochrane Rob Tool 2 and Review Manager version 5.4 to determine odds ratios and 95% confidence intervals.
RESULTS: According to the meta-analysis, a significant association was found between SLE risk and TNF-α-308 G/A polymorphism in allelic, dominant, and heterozygote models. However, no association was found between homozygous and recessive models. Interleukin-10 polymorphisms were not significantly associated with SLE risk in any model. Ethnicity-specific analysis revealed a significant association between the TNF-α allele and SLE susceptibility in Asian populations but not in Caucasians.
CONCLUSIONS: This meta-analysis identified a strong correlation between the TNF-α-308 G/A polymorphism and SLE susceptibility, particularly in Asian populations. However, no association was found between IL-10 polymorphisms and SLE. More extensive studies with diverse populations are required to validate and enhance these findings.