[ARB and anti-aging].

The aging process is unavoidably associated with a decline in functional physical capacity. To achieve the anti-aging, it is indispensable to tightly manage traditional risk factors and prevent several diseases, which lower the quality of life (QOL), including lifestyle-related diseases. Angiotensin II type 1 receptor blockers (ARB), anti-hypertensive agents, have various abilities beyond blood pressure lowering. Many basic researches and clinical trials have demonstrated the multiple functions of ARB (i.e., prevention of cardiac hypertrophy and new-onset of diabetes, renal protective and anti-oxidative capacities). In addition, recent researches show that new abilities of ARB as multi-organprotection (i.e., prevention of cognitive impairment and osteoporosis) are also worthy of remark. In the future, we are additionally anticipating the unlimited possibilities of ARB to aim for the successful aging.