Terapevticheskii arkhiv · 2012
[Survival of gout patients].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Аннотация
AIM: To assess survival and lethal outcome risk fahctors in gout patients.
MATERIAL AND METHODS: The study included 286 gout patients (246 males, 86% and 49 females, 14%) treated for gout in the Research Institute of Rheumatology from 2001 to 2006. From 2010 to May 2011 a telephone survey was made to obtain information about death of the above examinees. After the survey clinical condition of the dead patients was compared to that of survivors.
RESULTS: Of 286 participants of the trial, 38 did not response. By information from the relatives, there were 31 (12.5%) lethal outcomes of 248 patients. A cause of death in 20 patients, irrespective of age, were cardiovascular complications, 6 patients died of cancer; one patient--of chronic renal failure, one--of infection, one--of trauma and 2 - of unknown cause. Median of age at death was 62.1 years, median of gout duration--12.8 years. 65% of the deceased patients had risk factors of cardiovascular complications (type 2 diabetes mellitus, coronary heart disease, acute myocardial infarction, stroke, chronic cardiac failure). Median of time since examination in the clinic to death was 4.3 years.
CONCLUSION: Gout patients' mortality is high. 7-year survival was 85% in high overall mortality. 2/3 patients died of cardiovascular diseases. Survival of gout patients with normuricemia is the same ofthose with hyperuricemia. A high level of highly sensitive CRP is a factor of poor prognosis (death) for gout patients.
MATERIAL AND METHODS: The study included 286 gout patients (246 males, 86% and 49 females, 14%) treated for gout in the Research Institute of Rheumatology from 2001 to 2006. From 2010 to May 2011 a telephone survey was made to obtain information about death of the above examinees. After the survey clinical condition of the dead patients was compared to that of survivors.
RESULTS: Of 286 participants of the trial, 38 did not response. By information from the relatives, there were 31 (12.5%) lethal outcomes of 248 patients. A cause of death in 20 patients, irrespective of age, were cardiovascular complications, 6 patients died of cancer; one patient--of chronic renal failure, one--of infection, one--of trauma and 2 - of unknown cause. Median of age at death was 62.1 years, median of gout duration--12.8 years. 65% of the deceased patients had risk factors of cardiovascular complications (type 2 diabetes mellitus, coronary heart disease, acute myocardial infarction, stroke, chronic cardiac failure). Median of time since examination in the clinic to death was 4.3 years.
CONCLUSION: Gout patients' mortality is high. 7-year survival was 85% in high overall mortality. 2/3 patients died of cardiovascular diseases. Survival of gout patients with normuricemia is the same ofthose with hyperuricemia. A high level of highly sensitive CRP is a factor of poor prognosis (death) for gout patients.