Disseminated necrotizing panniculitis and pancreatic nodular hyperplasia in a dog.

An 8-year-old female Poodle had severe necrotizing skin disease characterized by numerous large red-purple, nonpruritic lesions. The larger lesions had soft, intensely discolored centers that contained sterile viscous blood-tinged material. Biopsies of the lesions revealed necrotizing panniculitis (subcutaneous fat necrosis). The dog did not respond to intensive therapy and euthanasia was performed. Necropsy findings included diffuse fat necrosis and pancreatic nodular hyperplasia. A pathoetiologic relation between pancreatic disease and diffuse fat necrosis in this dog was suggested.