Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2011
Movement preparation and cortical processing of afferent inputs in cortical tremor: an event-related (de)synchronization (ERD/ERS) study.
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Houdayer E, Degardin A, Salleron J, Bourriez J L, Defebvre L, Cassim F, Derambure P
Аннотация
OBJECTIVE: We sought to characterize cortical activity related to motor control in patients presenting with isolated cortical tremor, in order to determine whether or not myoclonus-related impairments are a source of event-related desynchronization/synchronization (ERD/ERS) disruption.
METHODS: Nine patients presenting with isolated cortical tremor were compared with controls. Mu and beta ERD/ERS were computed over the scalp and brain surfaces using 128-channel electroencephalographic (EEG) recording during voluntary and passive finger extensions. We recorded somatosensory-evoked potentials following median nerve stimulation and performed myoclonic jerk-locked back-averaging of EEG activity.
RESULTS: Back-averaging revealed a cortical premyoclonic spike in all patients. Five of the nine patients had exaggerated SEPs. The amplitude of mu ERD was greater in patients. Beta ERD/ERS did not differ from that seen in controls. Localizations of mu and beta ERD/ERS did not differ from controls and were identified in pre- and post-central sensorimotor cortical areas.
CONCLUSIONS: The present results suggest a hyperexcitability of the cortico-subcortical loops responsible for movement preparation and execution. Post-movement inhibition related to cortical processing of afferent input is unaffected in isolated cortical myoclonus.
SIGNIFICANCE: Intracortical abnormalities can differ in patients suffering from cortical myoclonus, according to whether or not the individuals have associated epileptic symptoms.
METHODS: Nine patients presenting with isolated cortical tremor were compared with controls. Mu and beta ERD/ERS were computed over the scalp and brain surfaces using 128-channel electroencephalographic (EEG) recording during voluntary and passive finger extensions. We recorded somatosensory-evoked potentials following median nerve stimulation and performed myoclonic jerk-locked back-averaging of EEG activity.
RESULTS: Back-averaging revealed a cortical premyoclonic spike in all patients. Five of the nine patients had exaggerated SEPs. The amplitude of mu ERD was greater in patients. Beta ERD/ERS did not differ from that seen in controls. Localizations of mu and beta ERD/ERS did not differ from controls and were identified in pre- and post-central sensorimotor cortical areas.
CONCLUSIONS: The present results suggest a hyperexcitability of the cortico-subcortical loops responsible for movement preparation and execution. Post-movement inhibition related to cortical processing of afferent input is unaffected in isolated cortical myoclonus.
SIGNIFICANCE: Intracortical abnormalities can differ in patients suffering from cortical myoclonus, according to whether or not the individuals have associated epileptic symptoms.