Science (New York, N.Y.) · 2025

Pre-European contact leprosy in the Americas and its current persistence.

СтатьяИсторическая статьяНазвание и аннотация: Перевод в очереди

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Lopopolo Maria, Avanzi Charlotte, Duchene Sebastian, Luisi Pierre, de Flamingh Alida, Ponce-Soto Gabriel Yaxal, Tressieres Gaetan, Neumeyer Sarah, Lemoine Frédéric, Nelson Elizabeth A, Iraeta-Orbegozo Miren, Cybulski Jerome S, Mitchell Joycelynn, Marks Vilma T, Adams Linda B, Lindo John, DeGiorgio Michael, Ortiz Nery, Wiens Carlos, Hiebert Juri, Bonifaz Alexandro, Montes de Oca Griselda, Paredes-Solis Vanessa, Franco-Paredes Carlos, Vera-Cabrera Lucio, Pereira Brunelli José G, Jackson Mary, Spencer John S, Salgado Claudio G, Han Xiang-Yang, Pearce Camron M, Warren Alaine K, Rosa Patricia S, de Finardi Amanda J, Belone Andréa de F F, Ferreira Cynthia, Suffys Philip N, Fontes Amanda N Brum, Vasconcellos Sidra E G, Schaub Roxane, Couppié Pierre, Drak Alsibai Kinan, Hernández-Castro Rigoberto, Silva Miranda Mayra, Estrada-Garcia Iris, Jurado-Santacruz Fermin, Orlando Ludovic, Schroeder Hannes, Quintana-Murci Lluis, Del Papa Mariano, Lahiri Ramanuj, Malhi Ripan S, Rasmussen Simon, Rascovan Nicolás

Аннотация

Leprosy, caused primarily by Mycobacterium leprae, is considered a disease introduced into the Americas during European colonization. However, the recent discovery of a second pathogen causing leprosy, M. lepromatosis, mainly found in the Americas, challenges this view. Here, we show that M. lepromatosis infected humans in the Americas before European contact. By screening 389 ancient and 408 contemporary samples, we have expanded the genetic data available for the species. Phylogenetic analyses revealed distinct human-infecting clades of M. lepromatosis, with one dominating North America since colonial times. The presence of millennia-old strains in North and South America indicates that M. lepromatosis may have been widespread during the Late Holocene, demonstrating that M. lepromatosis leprosy has a long-standing history in the Americas before European arrival.

Предметные рубрики MeSH

Humans Europe History, Ancient Leprosy Leprosy, Lepromatous Mycobacterium leprae North America Phylogeny South America Mycobacterium

Pre-European contact leprosy in the Americas and its current persistence.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH