[Endoscopic studies of the stomach tolerance of ibuprofen: comparison of 2 galenically different preparations].

In randomised crossover fashion, the gastric and duodenal tolerability of two different ibuprofen galenic formulations were directly compared in ten healthy volunteers. An endoscopic evaluation was performed after 7 and 14 days treatment. 300 mg Ibuprofen q.i.d. as pellets, as well as 600 mg Ibuprofen b.i.d. as dragees, evoked a lesion score of 1.6 +/- 0.3 and 1.7 +/- 0.4 after 7 days of treatment (n.s.). After 14 days, the lesion score under ibuprofen dragees was slightly higher (1.9 +/- 0.3) when compared with the pellet formulation (1.6 +/- 0.3). This difference did not reach statistical significance. Both ibuprofen preparations were well tolerated.