[New development in bisphosphonate treatment. Bisphosphonates for the treatment of glucocorticoid-induced osteoporosis].

Only bisphosphonates were shown to decrease the risk of vertebral fractures in patients taking glucocorticoids. Relative risk at 1 year treatment with bisphosphonates for incident vertebral fractures and non-vertebral fractures were 0.46 (95% confidence interval : 0.28 - 0.77) and 0.77 (95% confidence interval : 0.39 - 1.51) , respectively. Two years extension of the alendronate trial showed that relative risk for incident vertebral fractures was 0.10 (95% confidence interval : 0.01 - 0.90) .