Predictors of Mortality in Acute Myocardial Infarction Patients With Systemic Lupus Erythematosus.

Introduction Acute myocardial infarction (AMI) remains a leading cause of mortality globally, with systemic lupus erythematosus (SLE) posing additional risks for adverse outcomes. Methods This retrospective cohort study utilized data from the Healthcare Cost and Utilization Project National Inpatient Sample from 2016 to 2020 to investigate predictors of mortality among hospitalized AMI patients, stratified by SLE status. Results A total of 81,935 patients were included, with variables analyzed using multivariate logistic regression. Among SLE patients, being female, aged ≥65 years, and having a prolonged hospital stay >5 days were associated with higher mortality. Elective admissions were protective while non-Hispanic Black SLE patients showed reduced odds of mortality compared to their non-Hispanic White counterparts. Among non-SLE patients, predictors of increased mortality included being non-Hispanic Black and having prolonged hospital stays. Private insurance coverage was associated with lower mortality in this group. Conclusion These findings highlight critical patient- and hospital-related factors influencing mortality in AMI patients with and without SLE. Targeted strategies focusing on early recognition, effective interventions, and reducing healthcare disparities are essential to improve outcomes in this population.