The contribution of prolactin in the occurrence of premature cardiovascular disease predominantly through modulating the inflammatory cascade.

Cardiovascular disease, mainly coronary atherothrombosis, is an essential contributor to all-cause mortality, accounting for approximately 30% of all global deaths. Imbalances in hormone profiles may play a role in the evolution of atherothrombosis. In the last decade, our clinical research focused on the hormone prolactin (PRL) and its contribution to premature cardiovascular disease. In this narrative review, we aimed to give current insights into how PRL could modulate the inflammatory cascade within the microenvironment of the atherosclerotic plaque, which could lead to increased cardiovascular morbidity and mortality.