Знак центральной вены и повреждения парамагнитного обода: биомаркеры для точного дифференциального диагноза между множественным склерозом и мигренью.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Konzen Viviana Regina, Finkelsztejn Alessandro, Dos Santos Raquel Prates, de Souza Adolfo Moraes, Ruffini Matheus de Lima, Londero Renata Gomes, Duarte Juliana Ávila
Аннотация
Оригинал публикации
The central vein sign and paramagnetic rim lesions: biomarkers for an accurate differential diagnosis between multiple sclerosis and migraine.
OBJECTIVE: This study aimed to assess whether the evaluation of the central vein sign (CVS) and paramagnetic rim lesions (PRLs) using susceptibility-weighted magnetic resonance imaging (MRI) can distinguish multiple sclerosis (MS) from migraine.
MATERIALS AND METHODS: In this single-center observational study, we conducted a cross-sectional analysis of the CVS, determining the proportion of CVS-positive lesions per individual and absolute counts, using thresholds of 3 lesions (select3*) and 6 lesions (select6*), and of PRLs in participants with MS and in those with migraine, from 3.0-T MRI brain scans.
RESULTS: The study included 20 participants with MS, 20 with migraine, and 20 included as healthy controls. The proportion of participants with CVS-positive lesions was higher in the MS group than in the migraine group (61.8% vs. 10.4%), and PRLs were observed exclusively in the MS group. The presence of at least one PRL and the select6* criterion demonstrated the highest diagnostic accuracy within the study sample.
CONCLUSION: The detection of the CVS and of a PRL on 3.0-T MRI scans may serve as a reliable biomarker to differentiate MS from migraine.