[Trends in the determination of pharmacological intervention for osteoporosis].

WHO scientific group proposed a new strategy to identify cases for pharmacological intervention by integrating multiple factors of fracture risk. Ten independent risk factors for femoral neck fracture were presented including BMD (bone mineral density), previous fracture, bone chemical markers, and low body weight also their respective relative risk values. After adjusted for population risk, these factors were multiplied to obtain the integrated relative risk values. Then, nomograms were made to represent 10 year-fracture risk values to ages depending on the synthetic risk values. WHO group proposed to pharmacologically intervene when 10-yr risk values of femoral neck fracture exceeds 10-15%. It is a subject in many countries how they evaluate such a case-finding strategy for pharmacological intervention.