A Rare Pathogenic Masquerader of Pulmonary Disease: A Case Report.

This case report details a 61-year-old male patient with a history of chronic obstructive pulmonary disease (COPD) and significant smoking exposure, who presented with progressive anorexia, weight loss, nocturnal sweating, and worsening respiratory symptoms in early 2024. Imaging revealed bi-apical opacities with cavitation, and sputum cultures identified Mycobacterium szulgai, a rare nontuberculous mycobacterium (NTM). The patient was managed with a multi-drug regimen including azithromycin, rifampin, and ethambutol, targeting symptom relief, radiographic stability, and sputum conversion. Early treatment results demonstrated clinical improvement, weight gain, and decreased radiographic abnormalities, although sputum studies remained positive. This case underscores the diagnostic and therapeutic complexities of rare NTM infections in patients with underlying lung disease.