Медицинская библиотека · American journal of respiratory and critical care medicine · 2025

Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water.

Thomson Rachel M, Wheeler Nicole, Stockwell Rebecca E, Bryant Josephine, Taylor Steven L, Leong Lex E X, Le Trieu, Rogers Geraint B, Carter Robyn, Sherrard Laura J, Powell Harry, Simpson Graham, Patterson-Fahy Kirby, Wainwright Claire E, Floto R Andres, Parkhill Julian, Bell Scott C

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Аннотация

Rationale: Mycobacterium abscessus (MABS) group bacteria cause lethal infections in people with chronic lung diseases. Transmission mechanisms remain poorly understood; the detection of dominant circulating clones (DCCs) has suggested the potential for person-to-person transmission.

Objectives

This study aimed to determine the role of drinking water in the transmission of MABS.

Methods

A total of 289 isolates were cultured from respiratory samples (n = 231) and drinking water sources (n = 58) across Queensland, Australia. Measurements and Main

Results

Whole-genome sequences were analyzed to identify DCCs and determine relatedness. Half of the isolates (n = 144; 49.8%) clustered with previously described DCCs, of which 30 formed a clade within DCC5. Pan-genomic analysis of the water-associated DCC5 clade revealed an enrichment of genes associated with copper resistance. Four instances of plausible epidemiological links were identified between genomically related clinical and water isolates.

Conclusions

We provide evidence that drinking water is a reservoir for MABS and may be a vector in the chain of MABS infection.

Для цитирования: Thomson Rachel M, Wheeler Nicole, Stockwell Rebecca E, Bryant Josephine, Taylor Steven L, Leong Lex E X, Le Trieu, Rogers Geraint B, Carter Robyn, Sherrard Laura J, Powell Harry, Simpson Graham, Patterson-Fahy Kirby, Wainwright Claire E, Floto R Andres, Parkhill Julian, Bell Scott C. Infection by Clonally Related Mycobacterium abscessus Isolates: The Role of Drinking Water.. American journal of respiratory and critical care medicine. 2025. DOI: 10.1164/rccm.202409-1824oc.

Предметные рубрики MeSH

Humans Mycobacterium abscessus Drinking Water Mycobacterium Infections, Nontuberculous Queensland Male Female Water Microbiology Whole Genome Sequencing Middle Aged Aged

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