The Effect of Pregabalin on the Prevention of Succinylcholine-Induced Fasciculation and Myalgia.

PURPOSE: This study evaluates the effect of pregabalin on fasciculation and myalgia after using succinylcholine.

DESIGN

This randomized double-blind prospective study was conducted among 100 patients aged 20 to 60 years old.

METHODS

Pregabalin (300 mg) and placebo (in capsule form) were placed in similar containers. The results were analyzed by SPSS 23 software, and statistical analysis consisted of χ2 test and t test, and a P value less than .05 was considered significant.

FINDINGS: The mean pain score in the group receiving pregabalin was lower than the placebo group. According to the χ2 test, there was a significant difference between the two groups in the frequency of fasciculation (P = .003). Mean fasciculation severity in the pregabalin group was lower than placebo group. According to t test, there was a significant difference in the mean fasciculation severity between the two groups (P = .002).

CONCLUSIONS

This study showed that 300 mg of pregabalin was effective in reducing postoperative fasciculation and myalgia in patients treated with succinylcholine.