Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology · 1984
Antimicrobial activity of Obioactin.
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Osaki H, Furuya M, Nagasawa H, Suzuki N
Аннотация
A newly developed enzyme-hydrolyzed toxoplasma-hyperimmune bovine serum preparation, Obioactin , was examined for its anti-microbial and related actions against heterologous protozoa, bacteria, and viruses both in-vivo and in-vitro. An appreciable efficacy of Obioactin in a combination with nifurtimox, Lampit was observed in experimental Trypanosoma cruzi infections in mice. But prophylactic applications of the agent alone or joint with Lampit were in vain in mice. In-vitro digestion of certain bacteria in mouse peritoneal macrophages was accelerated in the presence of the agent being three to ten times stronger than that in untreated macrophages. Inhibitory effect of Obioactin on in-vitro infectivity of viruses was suggested.
Предметные рубрики MeSH
AnimalsAnti-Bacterial AgentsAnti-Infective AgentsCell LineChagas DiseaseChikungunya virusCricetinaeDrug Therapy, CombinationEncephalitis Virus, JapaneseFemaleHumansImmunoglobulinsListeriosisMacrophagesMaleMiceMice, Inbred StrainsNifurtimoxPhagocytosisRatsRats, Inbred StrainsSimplexvirusVirus Replication