Перспективы болезни Альцгеймера: противоречия и будущие направления.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Frisoni Giovanni B, Aho Emil, Brayne Carol, Ciccarelli Olga, Dubois Bruno, Fox Nick C, Frederiksen Kristian S, Gabay Cem, Garibotto Valentina, Hofmarcher Thomas, Jack Clifford R, Kivipelto Miia, Petersen Ronald C, Ribaldi Federica, Rowe Christopher C, Walsh Sebastian, Zetterberg Henrik, Hansson Oskar
Аннотация
Оригинал публикации
Alzheimer's disease outlook: controversies and future directions.
For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in randomised controlled trials. However, the results from phase 3 randomised controlled trials of anti-β amyloid monoclonal antibodies are interpreted in different ways, with some experts supporting a clinically meaningful disease-modifying effect, and others judging insufficient benefit-to-risk ratio and opposing market authorisation. In the final paper of this Series, we discuss these contrasting views, all of which wish to contribute to improvements in the quality of life of people with, or at risk of, Alzheimer's disease. We contrast the efficacy, societal costs, and generalisability of monoclonal antibodies for Alzheimer's disease to biologics for other conditions (eg, cancer, multiple sclerosis, and rheumatoid arthritis) and set this debate in the larger context of modern personalised medicine. We discuss current practice implications, future developments directed to β-amyloid and non-amyloid targets that might have more clinical efficacy and less adverse effects for those with the disease, and large-scale prevention interventions for those at risk.