[Effects of Yi-Fu Ning soft gelatin capsules on estrogen receptor expression in bone of postmenopausal osteoporosis rats].

OBJECTIVE

To investigate the effects of Yi-Fu Ning Soft Gelatin Capsules on estrogen receptor expression in bone of postmenopausal osteoporosis rats.

METHOD: 60 female Sprague-Dawley rats in 3-month were used, 50 of them were ovariectomized and randomly divided into 5 groups:ovariectomy (OVX), OVX with diethylstilbestrol tables (DT), OVX with YFN (high dose, middle dose and low dose), the others were sham-operated group. The rats were administrated initially in the fifth week after the operation. After 12 weeks the rats were killed. The blood and bones were collected to inspect. The content of Estrogen (E2) in serum was detected by radioimmunoassay method. The expression of estrogen receptor in bones was studied with Western blotting.

RESULT: After using the drugs, the content of E2, the estrogen receptor expression in bone increased significantly.

CONCLUSION

Yi-Fu Ning Soft Gelatin Capsules has a good effect on postmenopausal osteoporosis by increasing E2 and ER expression in bones.