Current medicinal chemistry · 2026
Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Diao Wuliang, Hu Yang, Chen Xiangyu, Li Weidong, Kpegah Julius Kormla Samuel Kekeli, Chen Xuan, Wang Mingzhu, Zhou Jianda, Li Ping
Аннотация
INTRODUCTION: Fat grafting procedures for body contouring and cosmetic reconstruction have received widespread attention.
METHODS: In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA), and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting.
RESULTS: By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1×109 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10.
CONCLUSION: The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.
METHODS: In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA), and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting.
RESULTS: By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1×109 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10.
CONCLUSION: The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.