Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium.

INTRODUCTION

Fat grafting procedures for body contouring and cosmetic reconstruction have received widespread attention.

METHODS

In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA), and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting.

RESULTS

By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1×109 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10.

CONCLUSION

The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.