Frontiers in neuroanatomy · 2026
Nucleus accumbens GLP-1 signaling and its role in reward and metabolic regulation: a systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Edwiges Maysa, Sá Susana I, Lopes Rui, Portela Cesar, Andrade José Paulo, Rocha-Neves João
Аннотация
INTRODUCTION: Glucagon-like peptide-1 (GLP-1) is an incretin hormone involved in glucose homeostasis, appetite regulation, and energy balance. Beyond its peripheral metabolic actions, growing evidence indicates that GLP-1 signalling within the central nervous system modulates reward-related processes. The nucleus accumbens (NAc), a key component of the mesolimbic reward pathway, represents a critical site where metabolic and motivational signals converge. However, the role of GLP-1 signalling within the human NAc remains incompletely understood. This systematic review aimed to synthesize current human evidence on GLP-1 expression and receptor signalling in the NAc and their role in reward and metabolic regulation.
METHODS: A systematic search of PubMed, Scopus, and Web of Science was conducted in December 2025. Human studies assessing GLP-1 or GLP-1 receptor (GLP-1R) in relation to NAc structure, function, or connectivity were included. Study selection and data extraction were performed independently by two reviewers.
RESULTS: From 276 screened records, five studies were included, totalling 284 participants. No consistent evidence emerged for direct GLP-1-related alterations in isolated NAc activation or GLP-1R expression. Instead, GLP-1 modulation of mesolimbic connectivity, particularly between the NAc and orbitofrontal cortex (OFC), was observed.
DISCUSSION: Current human evidence suggests that GLP-1 modulates reward processing primarily through cortico-striatal connectivity rather than localized changes within the NAc, with potential translational implications for obesity and addiction. Further harmonized neuroimaging studies incorporating direct pharmacological manipulation are needed to clarify NAc-specific GLP-1 mechanisms.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251250453.
METHODS: A systematic search of PubMed, Scopus, and Web of Science was conducted in December 2025. Human studies assessing GLP-1 or GLP-1 receptor (GLP-1R) in relation to NAc structure, function, or connectivity were included. Study selection and data extraction were performed independently by two reviewers.
RESULTS: From 276 screened records, five studies were included, totalling 284 participants. No consistent evidence emerged for direct GLP-1-related alterations in isolated NAc activation or GLP-1R expression. Instead, GLP-1 modulation of mesolimbic connectivity, particularly between the NAc and orbitofrontal cortex (OFC), was observed.
DISCUSSION: Current human evidence suggests that GLP-1 modulates reward processing primarily through cortico-striatal connectivity rather than localized changes within the NAc, with potential translational implications for obesity and addiction. Further harmonized neuroimaging studies incorporating direct pharmacological manipulation are needed to clarify NAc-specific GLP-1 mechanisms.
SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251250453.