Лечение более старших пациентов с множественным склерозом прекратилось.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Frau Jessica, Schiavetti Irene, Landi Doriana, Lapucci Caterina, Saporito Valentino, Di Gianvito Valentina, Cavalli Nicola, Atzei Letizia, Signori Alessio, Girolama Marfia, Cocco Eleonora
Аннотация
Оригинал публикации
Treatment discontinuation in older patients with multiple sclerosis.
OBJECTIVE: To examine disease activity in older people with multiple sclerosis (pwMS) following discontinuation of disease-modifying treatments (DMTs).
METHODS: PwMS aged 60 years or older who discontinued DMTs were included. Data on clinical and demographic factors, as well as new or gadolinium-enhancing lesions on magnetic resonance imaging (MRI) during the final year on DMT and after discontinuation, were analysed. McNemar's test was used to assess intra-patient MRI activity differences before and after discontinuation. Cox regression evaluated factors influencing MRI activity post-discontinuation.
RESULTS: We included 114 pwMS (78.1 % female) from 3 Italian MS centres who discontinued a DMT. The mean age at disease onset was 42.4 years (SD: 11.74), and at DMT discontinuation, 65.7 years (SD: 3.84). Median EDSS was 5.5 (IQR: 2.5-6.0). First-line DMTs were discontinued in 105 participants. No significant changes in MRI activity before and after discontinuation were observed (p = 0.5). Pre-discontinuation MRI activity was the only factor associated with post-discontinuation activity (p = 0.021).
CONCLUSIONS: In pwMS aged over 60 years, discontinuing DMTs does not increase the risk of MRI-detected disease activity. Discontinuation may be a viable option for this population.