Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis.

Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6-month modified ketogenic diet in 39 participants and an 8-week randomized comparison of intermittent and daily calorie restriction versus a weight-stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (p = 0.009) and intermittent calorie restriction (p = 0.04), whereas daily calorie reduction had no effect. These findings indicate that fasting-mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. ANN NEUROL 2025;98:1278-1282.