[Value of transdermal hormone substitution for postmenopausal osteoporosis].

The osteoporosis is a major public health problem occurring primarily among the postmenopausal women. The relationship to the loss of ovarian function is undoubtful. The consequence of this knowledge is to substitute the hormone deficiency. Hormone replacement therapy (HRT) is effective with oral, subcutaneous, parenteral, and transdermal application. The transdermal hormone replacement therapy for prevention and therapy (early phase) of postmenopausal osteoporosis is effective and sure. The osteoprotective effect was demonstrated in multiple studies. The effectiveness of the HRT can be demonstrated by osteodensitometry and measuring markers of bone resorption.