Journal of dentistry · 2026
The role of periostin in mechanotransduction in musculoskeletal and periodontal tissues: A scoping review.
СтатьяScoping ReviewНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Na Nan Daneeya, Wahyudi Rahman, Changsiripun Chidsanu, Osathanon Thanaphum, Everts Vincent, Limjeerajarus Chalida Nakalekha, Limjeerajarus Nuttapol
Аннотация
OBJECTIVES: Periostin is a mechanosensitive matricellular protein that is upregulated by mechanical stimulation and plays key roles in remodeling and repair in periodontal tissues, making it a promising target for applications; however, it is not yet used as a therapeutic agent. This scoping review mapped the literature on periostin and summarized the experimental models, cell types, and signaling pathways involved in periostin-mediated mechanotransduction.
DATA SOURCES: MEDLINE via PubMed, Scopus, and ScienceDirect were systematically searched for studies published between 2006 and 2026.
STUDY SELECTION AND RESULTS: Eligible studies included peer-reviewed original research articles, such as randomized controlled trials, non-randomized studies, observational studies, and laboratory-based experimental studies. After screening, 32 studies met the inclusion criteria. The studies consistently showed that periostin acts as a protective matrix-associated molecule that preserves tissue architecture, reinforces mechanical stability, and supports cellular tolerance to mechanical stress and its absence impaired tissue adaptation and homeostasis under biomechanical loading.
CONCLUSION: Current evidence supports periostin as both a marker of force responsiveness and a functional mediator of tissue adaptation under mechanical force stimulation, highlighting its therapeutic potential in musculoskeletal and periodontal regeneration.
CLINICAL SIGNIFICANCE: Periostin is a promising biomarker of mechanical force responsiveness and a therapeutic target for tissue regeneration. However, establishing standardized clinical assays, diagnostic thresholds, and validated delivery protocols remains necessary before clinical translation.
DATA SOURCES: MEDLINE via PubMed, Scopus, and ScienceDirect were systematically searched for studies published between 2006 and 2026.
STUDY SELECTION AND RESULTS: Eligible studies included peer-reviewed original research articles, such as randomized controlled trials, non-randomized studies, observational studies, and laboratory-based experimental studies. After screening, 32 studies met the inclusion criteria. The studies consistently showed that periostin acts as a protective matrix-associated molecule that preserves tissue architecture, reinforces mechanical stability, and supports cellular tolerance to mechanical stress and its absence impaired tissue adaptation and homeostasis under biomechanical loading.
CONCLUSION: Current evidence supports periostin as both a marker of force responsiveness and a functional mediator of tissue adaptation under mechanical force stimulation, highlighting its therapeutic potential in musculoskeletal and periodontal regeneration.
CLINICAL SIGNIFICANCE: Periostin is a promising biomarker of mechanical force responsiveness and a therapeutic target for tissue regeneration. However, establishing standardized clinical assays, diagnostic thresholds, and validated delivery protocols remains necessary before clinical translation.