Journal of orthopaedics · 2020
Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome.
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Hatami Maryam, Sobhan Mohammad Reza, Dastgheib Seyed Alireza, Jarahzadeh Mohammad Hossein, Jafari Mohammadali, Yadegari Amirhossein, Sadeghizadeh-Yazdi Jalal, Neamatzadeh Hossein
Аннотация
BACKGROUND: Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS.
METHODS: In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay.
RESULTS: There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls.
CONCLUSIONS: Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.
METHODS: In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay.
RESULTS: There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls.
CONCLUSIONS: Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.