The Journal of rheumatology · 2016
Analysis of Systemic Sclerosis-associated Genes in a Turkish Population.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Carmona F David, Onat Ahmet Mesut, Fernández-Aranguren Tamara, Serrano-Fernández Alberto, Robledo Gema, Direskeneli Haner, Sawalha Amr H, Yavuz Sule, Martín Javier
Аннотация
OBJECTIVE: To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population.
METHODS: There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations.
RESULTS: Except for ATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E-05, OR 1.76; CD247: p = 2.20E-03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.
CONCLUSION: The genetic component of SSc seems to be similar between Turks and Europeans.
METHODS: There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations.
RESULTS: Except for ATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E-05, OR 1.76; CD247: p = 2.20E-03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes.
CONCLUSION: The genetic component of SSc seems to be similar between Turks and Europeans.
Предметные рубрики MeSH
AdultAllelesAutophagy-Related Protein 5CD3 ComplexCase-Control StudiesEndodeoxyribonucleasesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInterferon Regulatory FactorsInterleukin-12 Subunit p35MaleMiddle AgedPhenotypePolymorphism, Single NucleotideSTAT4 Transcription FactorScleroderma, SystemicTurkey