Molecular pain · 2018
Involvement of neutrophils and interleukin-18 in nociception in a mouse model of muscle pain.
СтатьяНазвание и аннотация: Перевод в очереди
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Yoshida Shinichirou, Hagiwara Yoshihiro, Tsuchiya Masahiro, Shinoda Masamichi, Koide Masashi, Hatakeyama Hiroyasu, Chaweewannakorn Chayanit, Yano Toshihisa, Sogi Yasuhito, Itaya Nobuyuki, Sekiguchi Takuya, Yabe Yutaka, Sasaki Keiichi, Kanzaki Makoto, Itoi Eiji
Аннотация
Muscle pain is a common condition that relates to various pathologies. Muscle overuse induces muscle pain, and neutrophils are key players in pain production. Neutrophils also play a central role in chronic pain by secreting interleukin (IL)-18. The aim of this study was to investigate the involvement of neutrophils and IL-18 in a mouse model of muscle pain. The right hind leg muscles of BALB/c mice were stimulated electrically to induce excessive muscle contraction. The left hind leg muscles were not stimulated. The pressure pain threshold, number of neutrophils, and IL-18 levels were investigated. Furthermore, the effects of the IL-18-binding protein and Brilliant Blue G on pain were investigated. In stimulated muscles, pressure pain thresholds decreased, and neutrophil and IL-18 levels increased compared with that in non-stimulated muscles. The administration of IL-18-binding protein and Brilliant Blue G attenuated hyperalgesia caused by excessive muscle contraction. These results suggest that increased IL-18 secretion from larger numbers of neutrophils elicits mechanical hyperalgesia.