[Antinociceptive efficacy of QO-58 in the monosodium lodoacetate rat model for osteoarthritis pain].

Objective

To determine the effects of QO-58 on pain behavior associated with monosodium iodoacetate (MIA)-induced OA.

Methods

The OA model was established with an intra-articular injection of 3 mg/50 MIA through the right patellar ligament. Then the model rats were treated with 50 mg/kg QO-58 by intraperitoneal injection, and pain-related behaviors were assessed by single administration and multiple administrations of QO-58.

Results

Single adminstration of QO-58 increased the mechanical threshold and prolonged the withdrawal latency of OA pain with the antinociceptive effect occurring at 6 h and 10 h. Compound QO-58 was administered intraperitoneally once a day from day 10 to 14. QO-58 significantly increased the mechanical threshold and prolonged the withdrawal latency of OA rats at 12 and 14 days.

Conclusion

QO-58 showed antinociceptive effects for OA pain in the MIA model after pain development. QO-58 may be an alternative therapeutic treatment for OA.