[Contemporary views on use of estrogen replacement therapy in postmenopausal women. I. Hormone therapy in women with menopausal osteoporosis].

Osteoporosis is a great problem in postmenopausal women. It begins 4--5 years after a last period and appears in clinical form in about 25-44% women. Basic irregularity is osteopenia as a result of bone resorption superiority. Many observations lead to conclusion that postmenopausal osteoporosis follows estrogens deficiency, that play a substantial role in bone metabolism. Estrogen therapy reverses a process of osteoporosis. Periodic treatment, with use of progestogens, should be performed, under condition of close endometrium and breast control. Progestogens also increase, depending on dose and kind of hormone, mechanisms preventing bone mass lost.