Pediatric surgery international · 2021
Muscle imbalance as a cause of scoliosis: a study in a fetal lamb abdominal wall defect model.
СтатьяНазвание и аннотация: Перевод в очереди
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Kawaguchi Kohei, Obayashi Juma, Koike Junki, Tanaka Kunihide, Seki Yasuji, Nagae Hideki, Ohyama Kei, Furuta Shigeyuki, Valsenti Gianluca, Pringle Kevin C, Kitagawa Hiroaki
Аннотация
BACKGROUND: We created abdominal wall defects (AWD) in fetal lambs to investigate possible causes of scoliosis.
METHODS: We incised the upper abdominal wall (including Rectus) in 60-day gestation fetal lambs, from the midline to either the right (Group A) or left (Group B) costal margin, in 14 lambs carried by 7 ewes. They were delivered by cesarean section at term (about 145 days). Scoliosis was evaluated by anterio-posterior X-rays, determining the Cobb angle.
RESULTS: Four fetuses in Group A and 3 in Group B survived. There were 3 successful AWD lambs Group A and 2 in Group B. One lamb in each group survived with the AWD covered with a thick capsule. The convexity of spinal curve was the direction of scoliosis. Right scoliosis was only seen in the 4 Group A lambs. Left scoliosis was only seen in Group B lambs (2/3, 67%). The mean Cobb angle was 41.7 ± 11.5° in Group A and in Group B the Cobb angles were 59.6o and 60.6°. Overall, 4/5 lambs with organ prolapse (80%) and both lambs without organ prolapse had scoliosis.
CONCLUSION: Muscle imbalance may contribute to the development of scoliosis in a fetal lamb AWD model.
METHODS: We incised the upper abdominal wall (including Rectus) in 60-day gestation fetal lambs, from the midline to either the right (Group A) or left (Group B) costal margin, in 14 lambs carried by 7 ewes. They were delivered by cesarean section at term (about 145 days). Scoliosis was evaluated by anterio-posterior X-rays, determining the Cobb angle.
RESULTS: Four fetuses in Group A and 3 in Group B survived. There were 3 successful AWD lambs Group A and 2 in Group B. One lamb in each group survived with the AWD covered with a thick capsule. The convexity of spinal curve was the direction of scoliosis. Right scoliosis was only seen in the 4 Group A lambs. Left scoliosis was only seen in Group B lambs (2/3, 67%). The mean Cobb angle was 41.7 ± 11.5° in Group A and in Group B the Cobb angles were 59.6o and 60.6°. Overall, 4/5 lambs with organ prolapse (80%) and both lambs without organ prolapse had scoliosis.
CONCLUSION: Muscle imbalance may contribute to the development of scoliosis in a fetal lamb AWD model.