Scientific reports · 2021
Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Pandolfi Elisabetta, Panera Nadia, Alisi Anna, Carloni Emanuela, Russo Luisa, Campagna Ilaria, Rizzo Caterina, Concato Carlo, Linardos Giulia, Piccioni Livia, Jackson Sally, Villani Alberto, Midulla Fabio, Tozzi Alberto E
Аннотация
Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections. Nasopharyngeal aspirate (NPA) samples were taken from children, aged < 1 year, positive for Rhinovirus, Bordetella pertussis and for Rhinovirus and Bordetella pertussis. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Our results show that co-infections display a different inflammatory pattern compared to single infections, suggesting that a chronic inflammation caused by one of the two pathogens could be the trigger for exacerbation in co-infections.