IMPACT OF PERCUTANEOUS CORONARY INTERVENTION ON MARKERS OF MATRIX DEGRADATION AND ENDOTHELIAL-DEPENDENT MEDIATORS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2.

Aim of study ‒ assess an impact of percutaneous coronary intervention on markers of matrix degradation (MMP-13, TIMP-4) and endothelial-dependent mediators (sVE-cadherin, ADMA) in patients with acute myocardial infarction and diabetes mellitus type 2. 110 patients with AMI were enrolled in the study, 70 patients had concomitant diabetes mellitus type 2. They were additionally divided into two subgroups depending on the treatment (percutaneous coronary intervention or conservative therapy). According to the obtained results, misbalance of extracellular matrix degradation markers (MMP-13, TIMP-4) and endothelial dysfunction (sVE-cadherin, ADMA) were revealed in patients with acute myocardial infarction. Performing of PCI procedure contributes to the significant lowering of MMP-13, sVE-cadherin, ADMA and increasing of TIMP-4 in diabetic patients. It was establishted that performing of percutaneous coronary intervention in patients with acute myocardial infarction and diabetes mellitus type 2 contributes to the maintenance of extracellular matrix that prevents myocardium remodeling and improvement of endothelial function.