Anticancer research · 2016
Phase I Study of Triweekly Nab-Paclitaxel Combined with S-1 in Patients with HER2-negative Metastatic Breast Cancer.
Клиническое исследование I фазыСтатьяНазвание и аннотация: Перевод в очереди
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Sakaguchi Koichi, Nakatsukasa Katsuhiko, Taguchi Tetsuya
Аннотация
AIM: We conducted a phase I study to determine the maximum tolerated dose (MTD) and recommended dose (RD) of triweekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and S-1 combination therapy in patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC).
PATIENTS AND METHODS: This study was carried out with a 3+3 dose escalation design; patients with HER2-negative MBC received nab-paclitaxel at 180-260 mg/m2 on day 1 and S-1 at 65-80 mg/m2 daily on days 1-14, repeated every 3 weeks.
RESULTS: The MTD was level 3 (260 mg/m2 nab-paclitaxel with 80 mg/m2 S-1) and the RD was level 2 (260 mg/m2 nab-paclitaxel with 65 mg/m2 S-1). Dose-limiting toxicity was observed in two patients at level 3, who had grade 4 neutropenia and grade 3 myalgia, respectively.
CONCLUSION: The response rate was 66.7%. The clinical benefit rate was 77.8%. Our study shows the efficacy and the feasibility of this combination therapy.
PATIENTS AND METHODS: This study was carried out with a 3+3 dose escalation design; patients with HER2-negative MBC received nab-paclitaxel at 180-260 mg/m2 on day 1 and S-1 at 65-80 mg/m2 daily on days 1-14, repeated every 3 weeks.
RESULTS: The MTD was level 3 (260 mg/m2 nab-paclitaxel with 80 mg/m2 S-1) and the RD was level 2 (260 mg/m2 nab-paclitaxel with 65 mg/m2 S-1). Dose-limiting toxicity was observed in two patients at level 3, who had grade 4 neutropenia and grade 3 myalgia, respectively.
CONCLUSION: The response rate was 66.7%. The clinical benefit rate was 77.8%. Our study shows the efficacy and the feasibility of this combination therapy.