[Treatment of severe postmenopausal osteoporosis].

The paper is concerned with the results of therapy of a severe form of postmenopausal osteoporosis in 5 patients using the combination of estrogens, 1-alpha-hydroxycholecalciferol and calcitonin. The treatment with the above drugs was accompanied by marked improvement of the general status. It was characterized by an increase in daily calcium excretion with urine, normalization of the concentration of calcium, inorganic phosphorus and serum alkaline phosphatase activity. A conclusion was made that the combined use of estrogens and 1-alpha-hydroxycholecalciferol produced a more marked clinical effect than each drug separately.