Multiple sclerosis and related disorders · 2025
Saliva myelin basic protein (MBP) and oral health status as a biomarkers of relapsing-remitting multiple sclerosis.
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Kapel-Reguła Aleksandra, Chojdak-Łukasiewicz Justyna, Rybińska Anna, Duś-Ilnicka Irena, Radwan-Oczko Małgorzata
Аннотация
BACKGROUND: Oxidative stress and inflammation play critical roles in the pathophysiology of multiple sclerosis. This study aimed to assess the utility of saliva myelin basic protein (MBP) as a biomarker of disease activity in RRMS patients.
METHODS: Ninety-two relapsing-remitting multiple sclerosis patients (RRMS) and 51 healthy individuals were assessed for salivary MBP levels, antioxidant capacity, oral health, and clinical characteristics.
RESULTS: RRMS patients had significantly higher Approximal Plaque Index (API), salivary myelin basic protein (MBP) levels, and antioxidant capacity than controls. The correlation between antioxidant capacity and MBP levels suggests a connection between oxidative stress and demyelination. RRMS patients exhibited significantly poorer oral hygiene and more frequent oral complaints, although these were not directly associated with salivary biomarkers.
CONCLUSION: Saliva MBP may be a helpful non-invasive biomarker for monitoring disease activity in MS. Further longitudinal studies are warranted to confirm its diagnostic and prognostic utility.
METHODS: Ninety-two relapsing-remitting multiple sclerosis patients (RRMS) and 51 healthy individuals were assessed for salivary MBP levels, antioxidant capacity, oral health, and clinical characteristics.
RESULTS: RRMS patients had significantly higher Approximal Plaque Index (API), salivary myelin basic protein (MBP) levels, and antioxidant capacity than controls. The correlation between antioxidant capacity and MBP levels suggests a connection between oxidative stress and demyelination. RRMS patients exhibited significantly poorer oral hygiene and more frequent oral complaints, although these were not directly associated with salivary biomarkers.
CONCLUSION: Saliva MBP may be a helpful non-invasive biomarker for monitoring disease activity in MS. Further longitudinal studies are warranted to confirm its diagnostic and prognostic utility.