Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2008
Occupational infection due to Brucella abortus S19 among workers involved in vaccine production in Argentina.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wallach J C, Ferrero M C, Victoria Delpino M, Fossati C A, Baldi P C
Аннотация
The pathological consequences of exposure to the vaccine strain Brucella abortus S19 were evaluated in 30 employees from vaccine-manufacturing plants. Active brucellosis was diagnosed in 21 subjects, of whom only five recalled an accidental exposure. Clinical manifestations were mild, and only one patient presented a complication. After antimicrobial therapy, initially symptomatic patients either experienced clinical remission or had mild persistent symptoms. This is the first study reporting infection by B. abortus S19 among workers from vaccine-manufacturing plants, which in many cases was acquired from unnoticed exposures. Measures to improve the safety of B. abortus S19 handling should be implemented.