State of the art: the treatment of systemic lupus erythematosus.

PURPOSE OF REVIEW: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with dysregulated cells in the immune system. The disease affects organs like kidneys, nervous system, joints, and skin. To manage SLE effectively, novel treatments targeting immune system components have been developed. This review investigates the therapeutic potential of existing targeted therapies and explores future innovative approaches for well tolerated, personalized treatment.

RECENT FINDINGS: SLE treatment involves cytokine targets and specific immunologic pathways, with even small molecules involved.

SUMMARY: The advanced therapeutic options in SLE management give clinicians more tools to control disease activity according to personalized medicine.