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Войти в исследования BMC research notes · 2014
Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Meyer zu Schwabedissen Henriette E, Siegmund Werner, Kroemer Heyo K, Rollnik Jens D
Аннотация
BACKGROUND: Genetic factors as predictor of the individual outcome of drug therapy is one aim of personalized medicine approaches.
CASE PRESENTATION: We report a drug metabolism based analysis of genetic polymorphisms in a Caucasian patient receiving fluvastatin and telmisartan experiencing myotoxicity (myalgia and moderate creatine kinase elevation).
CONCLUSIONS: The obtained findings suggest that heterocygocity of cytochrome P450 CYP2C9*3 variant in combination with multidrug resistance-associated protein MRP2-24C > T functions as risk factor predisposing to experience drug-drug interaction combing those drugs.
CASE PRESENTATION: We report a drug metabolism based analysis of genetic polymorphisms in a Caucasian patient receiving fluvastatin and telmisartan experiencing myotoxicity (myalgia and moderate creatine kinase elevation).
CONCLUSIONS: The obtained findings suggest that heterocygocity of cytochrome P450 CYP2C9*3 variant in combination with multidrug resistance-associated protein MRP2-24C > T functions as risk factor predisposing to experience drug-drug interaction combing those drugs.
Предметные рубрики MeSH
AdultAngiotensin II Type 1 Receptor BlockersBase SequenceBenzimidazolesBenzoatesCreatine KinaseCytochrome P-450 CYP2C9DNA PrimersDrug Therapy, CombinationFatty Acids, MonounsaturatedFluvastatinHeterozygoteHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesMaleMultidrug Resistance-Associated Protein 2ATP-Binding Cassette, Sub-Family C ProteinsTelmisartan