[Evaluation of the effectiveness of intensive medical rehabilitation in MS patients through the prism of functional tests and serum neurofilaments].
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Sivertseva S A, Novikova O Yu, Chukreev V D, Yurovskikh I V, Belkin A A, Boyko A N
Аннотация
MATERIAL AND METHODS: The study included 39 patients with various forms of MS (remitting, secondary progressive, and primary progressive). Participants underwent a comprehensive assessment of motor and cognitive functions and quality of life (EDSS and Berg scales, 5STS, 6MWT, MOCA, SDMT, MSQOL-54 tests). The serum levels of NFL (NF light chains) and NFH (NF heavy chains) were measured using ELISA. The medical rehabilitation program included a 10-day inpatient course and an 8-day telerehabilitation. Follow-up measurements were performed after medical rehabilitation was completed.
RESULTS: There was no statistically significant decrease in the level of serum neurofilaments after the medical rehabilitation (p=0.686). However, there was a significant improvement in cognitive function (MoCA and SDMT scales, Beck's inventory, p<0.01), motor performance (Berg scale, EDSS, 5STS, 6MWT, p<0.05), and quality of life. A correlation between NF level and disability indicators (EDSS) and cognitive status was found.
CONCLUSION: The study's results confirm that intensive medical rehabilitation improves motor and cognitive functions in patients with MS but does not significantly affect the NF level, which indicates predominantly functional rather than structural changes in the nervous system. It emphasized the importance of a combined approach to MS management, including drug therapy and medical rehabilitative interventions. Studies with larger samples and more sensitive NF analysis methods, such as Simoa, are needed to further investigate the effect of medical rehabilitation on neurodegenerative processes.
Оригинал публикации
[Evaluation of the effectiveness of intensive medical rehabilitation in MS patients through the prism of functional tests and serum neurofilaments].
OBJECTIVE: To evaluate the effect of intensive medical rehabilitation on serum neurofilament (NF) levels and performance in multiple sclerosis (MS) patients.
MATERIAL AND METHODS: The study included 39 patients with various forms of MS (remitting, secondary progressive, and primary progressive). Participants underwent a comprehensive assessment of motor and cognitive functions and quality of life (EDSS and Berg scales, 5STS, 6MWT, MOCA, SDMT, MSQOL-54 tests). The serum levels of NFL (NF light chains) and NFH (NF heavy chains) were measured using ELISA. The medical rehabilitation program included a 10-day inpatient course and an 8-day telerehabilitation. Follow-up measurements were performed after medical rehabilitation was completed.
RESULTS: There was no statistically significant decrease in the level of serum neurofilaments after the medical rehabilitation (p=0.686). However, there was a significant improvement in cognitive function (MoCA and SDMT scales, Beck's inventory, p<0.01), motor performance (Berg scale, EDSS, 5STS, 6MWT, p<0.05), and quality of life. A correlation between NF level and disability indicators (EDSS) and cognitive status was found.
CONCLUSION: The study's results confirm that intensive medical rehabilitation improves motor and cognitive functions in patients with MS but does not significantly affect the NF level, which indicates predominantly functional rather than structural changes in the nervous system. It emphasized the importance of a combined approach to MS management, including drug therapy and medical rehabilitative interventions. Studies with larger samples and more sensitive NF analysis methods, such as Simoa, are needed to further investigate the effect of medical rehabilitation on neurodegenerative processes.