Sympathomimetic amines are a safe, highly effective therapy for several female chronic disorders that do not respond well to conventional therapy.

PURPOSE: To evaluate the efficacy of sympathomimetic amine therapy for women with chronic disorders including, but not limited to, pelvic pain.

MATERIALS AND

METHODS

Dextroamphetamine sulfate 15-mg extended release capsules were given to women with a variety of treatment refractory conditions including, but not limited to, pelvic pain. The dosage could be increased to 60 mg depending on tolerance to the medication and degree of improvement of the condition.

RESULTS

A very high percentage showed marked amelioration of their symptoms despite previous failure with medical or surgical therapy.

CONCLUSIONS

The human species, especially women, seem to be more prone to certain specific tissue permeability defects and diminished sympathetic tone, which compounds the problem, since the sympathetic nervous system controls permeability. Thus, besides pelvic pain and interstitial cystitis, dextroamphetamine sulfate, which seems to restore sympathetic tone possibly by increasing dopamine secretion to the nerve fiber, provides gratifying relief to a variety of chronic disorders. These other disorders include: severe headaches, inflammatory bowel disease, gastrointestinal motility disorders, fibromyalgia, and other musculoskeletal pain, chronic fatigue syndrome, and urticaria.