[The role of monocytes in the immunopathogenesis of multiple sclerosis].
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Zhetishev R R, Lopatina A V, Sviridova A A, Melnikov M V
Аннотация
MATERIAL AND METHODS: Forty-six scientific publications (1990-2024) on the role of monocytes in the pathogenesis of EAE and MS were analyzed.
RESULTS: Monocytes have been found to play an essential role in both the occurrence and persistence of autoimmune neuroinflammation. They penetrate the central nervous system (CNS) through the blood-brain barrier, produce pro-inflammatory cytokines, differentiate into macrophages/dendritic cells, and activate CD4+ T-cells. The change in both quantitative and functional characteristics of monocytes in MS is described.
CONCLUSION: Monocytes are involved in all stages of the immunopathogenesis of EAE and MS and largely mediate autoimmune demyelination in the CNS. Therefore, they can be considered a potential therapeutic target for MS.
Оригинал публикации
[The role of monocytes in the immunopathogenesis of multiple sclerosis].
OBJECTIVE: To systematize data on the role of monocytes in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
MATERIAL AND METHODS: Forty-six scientific publications (1990-2024) on the role of monocytes in the pathogenesis of EAE and MS were analyzed.
RESULTS: Monocytes have been found to play an essential role in both the occurrence and persistence of autoimmune neuroinflammation. They penetrate the central nervous system (CNS) through the blood-brain barrier, produce pro-inflammatory cytokines, differentiate into macrophages/dendritic cells, and activate CD4+ T-cells. The change in both quantitative and functional characteristics of monocytes in MS is described.
CONCLUSION: Monocytes are involved in all stages of the immunopathogenesis of EAE and MS and largely mediate autoimmune demyelination in the CNS. Therefore, they can be considered a potential therapeutic target for MS.