[Control of bone and cartilage lesions in rheumatoid arthritis with TNF inhibitors].

TNF inhibitors have provided the paradigm shift in the field of rheumatology. Now 5 TNF inhibitors(infliximab, etanercept, adalimumab, golimumab and certolizumab pegol)are available. Each agent has not only clinical efficacy but also suppressive effect of radiographic progression based on the large clinical trials. Prompt use of a TNF inhibitor after making a diagnosis of RA may be important to prevent joint deformities and to obtain better quality of life for RA patients.