Veterinary microbiology · 2002
Brucella proteomes--a review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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DelVecchio Vito G, Wagner Mary Ann, Eschenbrenner Michel, Horn Troy A, Kraycer Jo Ann, Estock Frank, Elzer Phil, Mujer Cesar V
Аннотация
The proteomes of selected Brucella spp. have been extensively analyzed by utilizing current proteomic technology involving 2-DE and MALDI-MS. In Brucella melitensis, more than 500 proteins were identified. The rapid and large-scale identification of proteins in this organism was accomplished by using the annotated B. melitensis genome which is now available in the GenBank. Coupled with new and powerful tools for data analysis, differentially expressed proteins were identified and categorized into several classes. A global overview of protein expression patterns emerged, thereby facilitating the simultaneous analysis of different metabolic pathways in B. melitensis. Such a global characterization would not have been possible by using time consuming and traditional biochemical approaches. The era of post-genomic technology offers new and exciting opportunities to understand the complete biology of different Brucella species.