Proceedings of the National Academy of Sciences of the United States of America · 2002
The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.
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Paulsen Ian T, Seshadri Rekha, Nelson Karen E, Eisen Jonathan A, Heidelberg John F, Read Timothy D, Dodson Robert J, Umayam Lowell, Brinkac Lauren M, Beanan Maureen J, Daugherty Sean C, Deboy Robert T, Durkin A Scott, Kolonay James F, Madupu Ramana, Nelson William C, Ayodeji Bola, Kraul Margaret, Shetty Jyoti, Malek Joel, Van Aken Susan E, Riedmuller Steven, Tettelin Herve, Gill Steven R, White Owen, Salzberg Steven L, Hoover David L, Lindler Luther E, Halling Shirley M, Boyle Stephen M, Fraser Claire M
Аннотация
The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.