Нетрин-1: Двойная роль в динамике нейроинфламмации и нейродегенеративных заболеваний.
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Farahani Hadiseh, Ganji Ali, Mosayebi Ghasem, Monfared Mohsen Ebrahimi, Ghazavi Ali
Аннотация
Оригинал публикации
Netrin-1: Dual Roles in Neuroinflammation and Neurodegenerative Disease Dynamics.
Netrin-1, a central axonal guidance molecule discovered for its role in neuronal development, is also essential in neurodegenerative diseases. Netrin-1 inhibits leukocyte migration and inflammation-related tissue damage outside the central nervous system. Therefore, it can be viewed as a potential biomarker for inflammatory activity in neurodegenerative diseases. Recent studies highlight the dual roles of Netrin-1 in neuroinflammation and neurodegenerative diseases. In the context of neurodegeneration, Netrin-1 demonstrates both protective and harmful effects. This review highlights recent advancements in research regarding the dual roles of Netrin-1 in neuroinflammation and neurodegeneration. We discuss its involvement in protecting the blood-brain barrier (BBB) and regulating immune cell migration and its effects on various neurodegenerative diseases. A greater understanding of the multifunctionality of Netrin-1 could potentially be employed in developing new treatment modalities.