Proceedings of the National Academy of Sciences of the United States of America · 2001
The genome sequence of the facultative intracellular pathogen Brucella melitensis.
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DelVecchio Vito G, Kapatral Vinayak, Redkar Rajendra J, Patra Guy, Mujer Cesar, Los Tamara, Ivanova Natalia, Anderson Iain, Bhattacharyya Anamitra, Lykidis Athanasios, Reznik Gary, Jablonski Lynn, Larsen Niels, D'Souza Mark, Bernal Axel, Mazur Mikhail, Goltsman Eugene, Selkov Eugene, Elzer Philip H, Hagius Sue, O'Callaghan David, Letesson Jean-Jacques, Haselkorn Robert, Kyrpides Nikos, Overbeek Ross
Аннотация
Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. The genome of B. melitensis strain 16M was sequenced and found to contain 3,294,935 bp distributed over two circular chromosomes of 2,117,144 bp and 1,177,787 bp encoding 3,197 ORFs. By using the bioinformatics suite ERGO, 2,487 (78%) ORFs were assigned functions. The origins of replication of the two chromosomes are similar to those of other alpha-proteobacteria. Housekeeping genes, including those involved in DNA replication, transcription, translation, core metabolism, and cell wall biosynthesis, are distributed on both chromosomes. Type I, II, and III secretion systems are absent, but genes encoding sec-dependent, sec-independent, and flagella-specific type III, type IV, and type V secretion systems as well as adhesins, invasins, and hemolysins were identified. Several features of the B. melitensis genome are similar to those of the symbiotic Sinorhizobium meliloti.