Journal of clinical practice and research · 2026
An Overlooked Risk Group in Adult Immunization: Vaccination Awareness and Knowledge in Patients with Cushing's Syndrome: A Cross-sectional Study.
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Vatansever Gökhan, Torun Berfin Nazlı, Işıkgöz Taşbakan Meltem, Çetinkalp Şevki
Аннотация
OBJECTIVE: The aim was to quantify registry-documented adult vaccine uptake among patients with Cushing's syndrome and to assess vaccine awareness in a voluntary survey subgroup.
MATERIALS AND METHODS: We conducted a record-based, retrospective, cross-sectional analysis of adults with confirmed Cushing's syndrome who were followed at a tertiary endocrinology clinic in Türkiye between January 1, 2017, and May 31, 2023. Vaccine histories were obtained from the national vaccination registry. In addition, a structured telephone questionnaire assessed awareness of vaccines for hepatitis A-D, pneumococcal disease, herpes zoster, influenza, and COVID-19 in a convenience sample of reachable, consenting patients. Analyses were descriptive; subgroup comparisons were exploratory.
RESULTS: The registry cohort included 119 patients (83.2% female; median age 51 years).Beyond SARS-CoV-2 vaccination, uptake of routinely indicated adult vaccines was low: tetanus-diphtheria vaccine (38.7%), pneumococcal conjugate vaccine (23.5%), hepatitis B vaccine (18.5%), influenza vaccine (2.5%), and meningococcal vaccine (1.7%). In the survey subgroup (n=35), awareness of hepatitis B infection was high (80.0%), but knowledge of hepatitis A (28.6%) and hepatitis B (51.4%)vaccines was limited. Although 80.0% reported awareness of pneumococcal vaccination, only 20.0% reported having received it; the most common reason cited was that it was perceived as unnecessary.
CONCLUSION: Adults with Cushing's syndrome had high SARS-CoV-2 vaccine uptake but substantial gaps in uptake and awareness of other recommended vaccines. Routine immunization assessment and proactive counseling in endocrinology clinics may help close preventable vaccination gaps.
MATERIALS AND METHODS: We conducted a record-based, retrospective, cross-sectional analysis of adults with confirmed Cushing's syndrome who were followed at a tertiary endocrinology clinic in Türkiye between January 1, 2017, and May 31, 2023. Vaccine histories were obtained from the national vaccination registry. In addition, a structured telephone questionnaire assessed awareness of vaccines for hepatitis A-D, pneumococcal disease, herpes zoster, influenza, and COVID-19 in a convenience sample of reachable, consenting patients. Analyses were descriptive; subgroup comparisons were exploratory.
RESULTS: The registry cohort included 119 patients (83.2% female; median age 51 years).Beyond SARS-CoV-2 vaccination, uptake of routinely indicated adult vaccines was low: tetanus-diphtheria vaccine (38.7%), pneumococcal conjugate vaccine (23.5%), hepatitis B vaccine (18.5%), influenza vaccine (2.5%), and meningococcal vaccine (1.7%). In the survey subgroup (n=35), awareness of hepatitis B infection was high (80.0%), but knowledge of hepatitis A (28.6%) and hepatitis B (51.4%)vaccines was limited. Although 80.0% reported awareness of pneumococcal vaccination, only 20.0% reported having received it; the most common reason cited was that it was perceived as unnecessary.
CONCLUSION: Adults with Cushing's syndrome had high SARS-CoV-2 vaccine uptake but substantial gaps in uptake and awareness of other recommended vaccines. Routine immunization assessment and proactive counseling in endocrinology clinics may help close preventable vaccination gaps.