Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion · 1996
[Unjustified disposal of transfusion blood because of antibodies against brucella].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Martínez-Canseco J, Hernández-Ramos I, Macías-Hernández A E, Cervera-López M, Medina-Valdovinos H, Orozco-Guzmán F
Аннотация
OBJECTIVES: To compare the slide microagglutination (SMA) test vs a gold standard test (tube agglutination test: SAT) for the detection of Brucella antibodies in order to evaluate the usefulness of SMA to discard transfusion blood units.
DESIGN: Prospective, comparative, cross sectional survey.
SETTING: City of Leon, State of Guanajuato, an endemic zone of brucellosis.
SAMPLES: 48 sera from blood units discarded for transfusion by three blood banks due to Brucella antibodies detected by SMA and 48 controls of accepted units.
METHODS: Determination of Brucella antibodies with the SMA and SAT tests.
RESULTS: The 48 control samples were negative with both tests; of the 48 discarded samples, in only seven sera we confirmed a titer > or = 1:80 by SAT; thus, 41 blood units (85%) may have been improperly rejected because the only test used by the blood banks was the SMA. In our hands, the SMA showed a sensitivity and negative predictive value of 100%, a specificity of 81%, and positive predictive value of 29%.
CONCLUSIONS: There was a high proportion of improper rejection of blood units for transfusion; Brucella antibodies at any titer detected by SMA should be followed by SAT testing.
DESIGN: Prospective, comparative, cross sectional survey.
SETTING: City of Leon, State of Guanajuato, an endemic zone of brucellosis.
SAMPLES: 48 sera from blood units discarded for transfusion by three blood banks due to Brucella antibodies detected by SMA and 48 controls of accepted units.
METHODS: Determination of Brucella antibodies with the SMA and SAT tests.
RESULTS: The 48 control samples were negative with both tests; of the 48 discarded samples, in only seven sera we confirmed a titer > or = 1:80 by SAT; thus, 41 blood units (85%) may have been improperly rejected because the only test used by the blood banks was the SMA. In our hands, the SMA showed a sensitivity and negative predictive value of 100%, a specificity of 81%, and positive predictive value of 29%.
CONCLUSIONS: There was a high proportion of improper rejection of blood units for transfusion; Brucella antibodies at any titer detected by SMA should be followed by SAT testing.